Youtake Oh, PhD
Instructor, Hematology & Medical Oncology
Emory University School of Medicine
Office: Winship Cancer Institute of Emory University
Phone: (404) 778-2268
Death receptor 5 (DR5) is a cell surface receptor and can initiate apoptosis upon overexpression or binding to its ligand (TRAIL). Accordingly, apoptosis-inducing DR5 agonistic antibodies have been developed and are being tested in the clinic. Ras (e.g., H-Ras or K-Ras) and B-Raf (i.e., V600E) mutations are common oncogenic events in human cancers, primarily through activation of the ERK/RSK signaling cascade. Interestingly, we have recently demonstrated that these mutations induce DR5 expression and the cancer cell lines with these mutations tend to be highly sensitive to a DR5 agonistic antibody.
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